Rivarox 10mg Tablet

Uses of Rivarox 10mg Tablet

• Treatment and Prevention of Blood Clots

How does Rivarox 10mg Tablet work?

Rivarox 10mg Tablet acts as an anticoagulant. It inhibits the activity of clotting factors made by the liver. Hence, it prevents the formation of blood clots in the body and makes the blood thin.

Side Effects of Rivarox 10mg Tablet

• Long or excessive bleeding
• Headache
• Pain in stomach
• Nausea or vomiting
• Loose motions or constipation
• Dizziness or fainting
• Indigestion
• Swelling or pain in limbs
• Skin rash or itching of the skin

Quick Suggestions:

• It is recommended to take Rivaroxaban at the same time every day and preferably with meals, especially at night. Taking it with food reduces the interaction with food or other medicines and helps maintain consistent blood levels.
• Rivaroxaban increases the risk of bleeding. It is important to exercise caution during activities that may cause injury or bleeding, such as shaving, cutting fingernails or toenails, using sharp objects, or participating in contact sports. If any bleeding is persistent or severe, seek medical attention promptly.
• Rivaroxaban may cause dizziness. It is advisable to avoid driving or engaging in activities that require mental focus until you know how the medication affects you. If dizziness persists or worsens, consult your doctor.
• If you are scheduled for surgery or dental treatment, inform your healthcare provider that you are taking Rivaroxaban. They may advise temporary discontinuation of the medication before the procedure to minimize the risk of bleeding.
• Inform your doctor if you have any kidney problems. Dose adjustments or special monitoring may be required in such cases.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The use of Rivaroxaban in pregnancy and lactation is not recommended without medical supervision.
• Do not stop taking Rivaroxaban without consulting your doctor. Avoid making any changes to your diet without first discussing it with your doctor.
• Cranberry juice, grapefruit juice, noni juice, and pomegranate juice may interact with Rivaroxaban and lead to unwanted side effects. It is advisable to avoid these juices while taking Rivaroxaban.
• It is recommended to avoid drinking alcohol while taking Rivaroxaban, as it can increase the risk of gastrointestinal ulceration or bleeding.
• Your doctor may recommend regular tests, such as platelet count, factor V assay, fibrinogen level test, prothrombin time test (PT or PT-INR), and international normalized ratio (INR), to assess your blood clotting time and monitor the effectiveness of the medication.

Indication of Rivarox 10mg Tablet

Rivaroxaban is used to control, treat, and prevention of conditions such as heart disease and strokes. This drug works by reducing the formation of blood clots.

Pharmacology

Rivaroxaban is a direct factor Xa inhibitor, which means it specifically targets and inhibits the activity of factor Xa, a key component in the blood coagulation cascade. By inhibiting factor Xa, rivaroxaban reduces the production of thrombin, an enzyme responsible for blood clot formation. It works by interrupting both the intrinsic and extrinsic pathways of the coagulation cascade.

It's important to note that rivaroxaban does not directly affect platelets and does not block thrombin (activated factor II). Instead, it acts on factor Xa to prevent the formation of blood clots. This mechanism of action makes rivaroxaban an effective anticoagulant medication for the prevention and treatment of various thromboembolic conditions.

Dosage & Administration of Rivarox 10mg Tablet

1. Administration:

• 10-mg tablet: May be taken with or without food.
• 15-mg and 20-mg tablets: Should be taken with food.

1. Adult Dose:

DVT Prophylaxis (Orthopedic Surgery):

• Knee replacement: 10 mg PO once daily for 12 days. May be taken with or without food.
• Hip replacement: 10 mg PO once daily for 35 days. May be taken with or without food.
• Administer the initial dose at least 6-10 hours after surgery once hemostasis has been established.

Nonvalvular Atrial Fibrillation:

• 20 mg PO once daily with the evening meal.

DVT or PE Treatment:

• 15 mg PO every 12 hours for 21 days with food, followed by 20 mg PO once daily for 6 months.

Reduce Risk for Recurrent DVT or PE:

• 20 mg PO once daily following the initial 6 months of treatment for DVT and/or PE.

Hepatic Impairment:

• Moderate impairment: Not studied. Use with caution.
• Avoid use in patients with moderate-to-severe impairment (Child-Pugh B) or severe impairment (Child-Pugh C) or with any hepatic disease associated with coagulopathy.

1. Child Dose:

• Safety and efficacy not established. Rivarox 10mg Tablet is not recommended for use in children. Consult your doctor for appropriate guidance.

1. Renal Dose:

Renal impairment (nonvalvular AF):

• CrCl 30-50 mL/min: 20 mg/day.
• CrCl 15-50 mL/min: 15 mg/day.
• ESRD on intermittent renal dialysis: 15 mg/day.

Renal impairment (postoperative thromboprophylaxis):

• CrCl >50 mL/min: Dose adjustment is not necessary.
• CrCl 30-50 mL/min: Use with caution; dose adjustment is not necessary.
• CrCl <30 mL/min: Avoid use.

Please follow your physician's instructions for the correct dose, duration, and frequency of Rivarox 10mg Tablet based on your specific medical condition. Do not stop taking the medication unless advised by your doctor.

Interaction

Drug-Drug Interactions:

• Antiplatelet drugs (warfarin, enoxaparin): Rivarox 10mg Tablet may interact with these drugs, which also have anticoagulant properties. Close monitoring of bleeding risk and appropriate dose adjustments may be necessary when using them together.
• Antiviral or HIV medicines (lopinavir, ritonavir): These medications may interact with Rivarox 10mg Tablet, potentially affecting its effectiveness or increasing the risk of bleeding. Careful monitoring and dose adjustments may be required.
• Painkillers (aspirin, ibuprofen): Concurrent use of these medications with Rivarox 10mg Tablet may increase the risk of bleeding. It is important to use them cautiously and follow your healthcare provider's guidance.
• Antiepileptic drugs (carbamazepine, phenytoin): These drugs may interact with Rivarox 10mg Tablet, potentially reducing its effectiveness. Close monitoring and dose adjustments may be necessary.
• Drugs for fungal or bacterial infections (fluconazole, erythromycin, clarithromycin): These medications may interact with Rivarox 10mg Tablet, affecting its metabolism and potentially increasing the risk of bleeding. Close monitoring and dose adjustments may be required.
• Herbal medication for depression (St. John's wort): St. John's wort may reduce the effectiveness of Rivarox 10mg Tablet. It is advisable to avoid concomitant use or consult with your healthcare provider.

Drug-Food Interactions:

• Grapefruit juice, cranberry juice, and green tea: These beverages may interact with Rivarox 10mg Tablet, potentially affecting its metabolism and increasing the risk of bleeding. It is advisable to avoid or limit the consumption of these substances while taking Rivarox 10mg Tablet.

Drug-Disease Interactions:

• Kidney, liver, or bleeding problems: Rivarox 10mg Tablet should be used with caution in patients with these conditions. Dose adjustments or close monitoring may be necessary.
• Heart problems and unstable blood pressure: Use Rivarox 10mg Tablet cautiously in patients with these conditions, as they may be at increased risk of bleeding. Regular monitoring and appropriate precautions are recommended.

Contraindications

• If you are allergic to rivaroxaban or any of the other ingredients of Rivarox 10mg Tablet.
• If you have liver disease.
• If you are pregnant or breastfeeding.
• If you have any bleeding disorder.
• If you have a stomach ulcer, brain injury, bleeding in the brain.
• If you have undergone brain or eye surgery recently.
• If you are taking other medicines, e.g. warfarin, dabigatran, apixaban, or heparin to prevent blood clots except in some conditions.

Pregnancy & Lactation

Rivaroxaban, including Rivarox 10, is classified as a pregnancy Category C medication. This means that there is limited information available about its use in pregnant women, and studies in pregnant women have not been conducted or are insufficient to establish its safety.

The use of Rivarox 10 or any Rivaroxaban formulation during pregnancy should only be considered if the potential benefits outweigh the potential risks. The dosage for pregnant women has not been established, and it is important to consult with a healthcare provider for individualized advice.

Regarding breastfeeding, rivaroxaban is not known to be excreted in human milk. However, the safety and effectiveness of rivaroxaban in nursing mothers have not been established. It is recommended to consult with a healthcare provider to assess the potential risks and benefits before using rivaroxaban while breastfeeding.

Precautions & Warnings

Use with caution in children: Rivarox 10mg Tablet should be used with caution in children. The safety and efficacy of the medication in pediatric populations may not be well-established, and dosage adjustments or specific considerations may be necessary.

Hair loss: Prolonged use of Rivarox 10mg Tablet may potentially cause hair loss. If you experience excessive hair loss while taking the medication, it is advisable to consult with your healthcare provider for further evaluation and guidance.

Regular blood tests: Regular blood tests are recommended while taking Rivarox 10mg Tablet to monitor blood clotting time and platelet levels. These tests help assess the effectiveness and safety of the medication and ensure appropriate management.

Allergies: If you are known to be allergic to Rivarox 10mg Tablet or any other medicines, it is important to inform your doctor. They can assess the potential risks and provide suitable alternatives if necessary.

Pregnancy and breastfeeding: It is advised to consult with a doctor before using Rivarox 10mg Tablet if you are pregnant or breastfeeding. The potential risks and benefits need to be evaluated to make an informed decision about the use of the medication during these periods.

Stomach ulcer, kidney or liver problems, high blood pressure, or bleeding problems: Inform your doctor about these conditions before taking Rivarox 10mg Tablet. They can assess the suitability of the medication and provide appropriate recommendations or precautions based on your specific health situation.

Storage Conditions

Store Rivarox 10mg Tablet at room temperature in a cool and dry place. Keep it out of the reach of children and pets.